Tamoxifen versus letrozole

Discussion in 'Canadian Pharmacy Meds' started by Muxeu04, 23-Aug-2019.

  1. dzutaro Well-Known Member

    Tamoxifen versus letrozole


    Accepted for publication 30 December 2015 Published 1 March 2016 Volume 2016:9 Pages 1077—1084 DOI https://doi.org/10.2147/OTT. S81087 Checked for plagiarism Yes Review by Single-blind Peer reviewers approved by Dr Jia Fan Peer reviewer comments 3 Editor who approved publication: Professor Daniele Santini School of Pharmaceutical Sciences, Jiangnan University, Wuxi, People’s Republic of China Abstract: The incidence rate of breast cancers in People’s Republic of China has increased in the last decade, and many cases are responsive to hormone therapies. The third-generation aromatase inhibitor letrozole inhibits estrogen production, and is more efficacious than the estrogen receptor inhibitor tamoxifen. In recent years, letrozole has been widely used to treat postmenopausal breast cancers in People’s Republic of China. Also, metastatic, premenopausal, and male breast cancers have been effectively treated by a combination of letrozole with cytotoxic, radiation, or other therapies. In this review, we provide a perspective and summary of recent advances in the use of letrozole for breast cancer in Chinese patients. Keywords: breast cancer, Chinese, letrozole Based on the diverse expression of estrogen receptor-α (ER-α), progesterone receptor, human epidermal growth factor receptor-2 (HER2), claudin, cytokeratin, and other molecular markers, a growing number of recognized biological subtypes of breast cancer have been identified, such as luminal A, luminal B, HER2, basal-like, and claudin-low. The antiestrogen tamoxifen has potent activity against estrogen receptor–positive breast cancer, but two nonsteroidal aromatase inhibitors, letrozole and anastrozole, show considerable advantages over tamoxifen with respect to patient survival and tolerability. To determine the optimal way to use letrozole and tamoxifen, we studied their effects on a breast tumor xenograft model, MCF-7Ca, that is responsive to both antiestrogens and aromatase inhibitors. Female ovariectomized BALB/c athymic nude mice carrying xenograft tumors were treated daily subcutaneously with one of the following first-line therapies for varying durations: no drug (control), tamoxifen (100 μg/day) alone, letrozole (10 μg/day) alone, both drugs at the same time, or alternating 4-week courses of each drug (beginning with a course of tamoxifen or beginning with a course of letrozole). Tumor volumes and weights were estimated using linear mixed-effects models. The time to tumor doubling was calculated, and tumor weights in the treatment groups were compared, with adjustments for multiple comparisons being made with either Tukey’s or Dunnett’s procedure. Second-line therapies (with tamoxifen, letrozole, or fulvestrant) were initiated when tumors doubled in size under first-line therapies. The times for doubling of tumor volume were as follows: control, 3–4 weeks; tamoxifen alone, 16 weeks; tamoxifen alternating with letrozole, 17–18 weeks; tamoxifen plus letrozole, 18 weeks; letrozole alternating with tamoxifen, 22 weeks; letrozole alone, 34 weeks. First-line treatment with letrozole was superior to treatment with tamoxifen alone or with the two drugs combined (at week 16, both First-line letrozole therapy extends time for tumor progression in this model relative to the other treatment regimens tested.

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    Nine hundred seven patients with advanced breast cancer were randomly assigned to receive 2.5 mg letrozole n = 453 or 20 mg tamoxifen n = 454 once. Dec 6, 2018. The hazard ratio for contralateral breast cancer with letrozole versus tamoxifen was 0.62 at 0 to 5 years and 0.47 at 5 to 10 years. However, this. J Steroid Biochem Mol Biol. 2003 Sep;863-5289-93. Letrozole versus tamoxifen in the treatment of advanced breast cancer and as neoadjuvant therapy.

    Find out what hormone therapy is, when you might have it, and the possible side effects. They control the growth and activity of normal cells. Before the menopause, the ovaries produce the hormones oestrogen and progesterone. After the menopause, oestrogen is made in body fat. These hormones can stimulate the growth of some breast cancer cells. Hormone treatments lower the levels of oestrogen or progesterone in the body, or block their effects. Hormone therapy is only likely to work if the breast cancer cells have oestrogen receptors (ER). Your doctor checks your cancer cells for these receptors when you are diagnosed. Side effects of hormone therapy can include hot flashes and other menopausal symptoms.(AROMASIN/NOVARTIS/HEALTH) If your breast cancer tumor is estrogen- and/or progesterone- receptor (ER/PR) positive, that's good news because it means you have more treatment options and may benefit from hormone therapy. Tamoxifen—which has been around for decades—has been shown to prevent the chances of a recurrence in high-risk women by almost 50%. And in March 2008, researchers announced that drugs in a newer class called aromatase inhibitors (AIs) stopped breast cancer recurrence for postmenopausal patients who had completed tamoxifen treatment (even years after). In the vast majority of cases, a woman whose cancer is positive for estrogen is also positive for progesterone. "If you're positive for both, we know you will be much more responsive to anti-estrogen therapy," says Julie R. Gralow, MD, director of breast medical oncology at the University of Washington and Fred Hutchinson Cancer Research Center in Seattle. Two types of anti-estrogen drugs Tamoxifen (Nolvadex) and raloxifene (Evista) are part of a drug class called selective estrogen receptor modulators (SERMs).

    Tamoxifen versus letrozole

    Impact of Tamoxifen on the Pharmacokinetics and Endocrine Effects of., Adjuvant Letrozole and Tamoxifen Alone or Sequentially in.

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  7. Nov 26, 2018. Luminal breast cancer has a long natural history, with recurrences continuing beyond 10 years after diagnosis. We analyzed long-term.

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    Aug 4, 2015. The magnitude of benefit of adjuvant letrozole is greater for patients diagnosed with lobular carcinoma versus ductal carcinoma, according to a. RATIONALE Estrogen can stimulate the growth of breast cancer cells. Hormone therapy using letrozole may fight breast cancer by reducing the production of. Jan 18, 2019. i had been on Tamoxifen for 8 years and will switch to Letrozole as one. Have you discussed your problems with Letrozole with your BCN or.

     
  8. SkyWalker Well-Known Member

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