Tamoxifen use

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  1. iwan111 Moderator

    Tamoxifen use


    Hormones are substances that function as chemical messengers in the body. They affect the actions of cells and tissues at various locations in the body, often reaching their targets through the bloodstream. The hormones estrogen and progesterone are produced by the ovaries in premenopausal women and by some other tissues, including fat and skin, in both premenopausal and postmenopausal women and men. Estrogen promotes the development and maintenance of female sex characteristics and the growth of long bones. Progesterone plays a role in the menstrual cycle and pregnancy. Estrogen and progesterone also promote the growth of some breast cancers, which are called hormone-sensitive (or hormone-dependent) breast cancers. Hormone-sensitive breast cancer cells contain proteins called hormone receptors that become activated when hormones bind to them. For some women with breast cancer, taking adjuvant tamoxifen (Nolvadex®) for 10 years after primary treatment leads to a greater reduction in breast cancer recurrences and deaths than taking the drug for only 5 years, according to the results of a large international clinical trial. The findings from the ATLAS trial—presented at the San Antonio Breast Cancer Symposium (SABCS) and published in on December 5, 2012—are likely to change clinical practice, several researchers said. Nearly 7,000 women with early-stage, estrogen receptor-positive breast cancer were enrolled in the trial between 19. After taking tamoxifen for 5 years, participants were randomly assigned to continue taking tamoxifen for another 5 years or to stop taking it. From 5 to 9 years after the women began tamoxifen therapy, there was little difference in outcomes between the two treatment groups. This finding is consistent with those from other trials of adjuvant tamoxifen therapy, which showed that 5 years of tamoxifen can substantially reduce the risk of the cancer returning and of cancer death in the next few years, what one of the trial investigators, Richard Gray, MSc, of Oxford University, UK, called a "carryover effect." The improved outcomes with longer tamoxifen use emerged only after the 10-year mark, Gray explained during an SABCS press briefing. Among the women who took tamoxifen for 10 years, the risk of breast cancer returning between 10 and 14 years after starting tamoxifen was 25 percent lower than it was among women who took it for 5 years, and the risk of dying from breast cancer was nearly 30 percent lower.

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    For premenopausal patients with receptor-positive early breast cancer, administration of tamoxifen for 5 years constitutes the main adjuvant endocrine therapy. However, tamoxifen may not be suitable for all women at high risk of developing the disease. Women who should definitely not use tamoxifen include pregnant. These findings have led to increased use of tamoxifen for more than 5 years, especially among premenopausal women who can't take aromatase inhibitors.

    Tamoxifen is a drug called an estrogen receptor antagonist, which works by blocking the receptor so that estrogen can’t work its usual effects within the body. Estrogen is an important hormone in the female body and plays a big role in some types of breast cancer. As a result, tamoxifen is commonly used to prevent breast cancer from appearing or coming back in women who are at a high risk of or have a history of breast cancer. This is not the only way that tamoxifen can be used, however, and there are several alternative ways that this drug can be used to offer a benefit. The following information goes into more detail about alternative uses of the medication and how it can be used. Some individuals that experience premature puberty may notice symptoms of Mc Cune-Albright syndrome, such as bone disfiguration and skin discoloration. Tamoxifen can be used to decrease the rate of bone maturation and alter the predicted adult height, which is usually lower in those with premature puberty. In 2006, the large STAR clinical study concluded that raloxifene is equally effective in reducing the incidence of breast cancer, but after an average 4-year follow-up, although the difference was not statistically significant, there were 36% fewer uterine cancers and 29% fewer blood clots in women taking raloxifene than in women taking tamoxifen. Tamoxifen improves fertility in males with infertility by disinhibiting the hypothalamic–pituitary–gonadal axis (HPG axis) via ER antagonism and thereby increasing the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) and increasing testicular testosterone production. It is taken as a preventative measure in small doses, or used at the onset of any symptoms such as nipple soreness or sensitivity. Other drugs are taken for similar purposes such as clomifene and the anti-aromatase drugs which are used in order to try to avoid the hormone-related adverse effects. Occasionally tamoxifen is used in treatment of the rare conditions of retroperitoneal fibrosis A report in September 2009 from Health and Human Services' Agency for Healthcare Research and Quality suggests that tamoxifen, raloxifene, and tibolone used to treat breast cancer significantly reduce invasive breast cancer in midlife and older women, but also increase the risk of adverse side effects. Some cases of lower-limb lymphedema have been associated with the use of tamoxifen, due to the blood clots and deep vein thrombosis (DVT) that can be caused by this medication. Resolution of the blood clots or DVT is needed before lymphedema treatment can be initiated.

    Tamoxifen use

    Tamoxifen Side Effects, Dosage, Uses, and More - Healthline, Tamoxifen & Breast Cancer Cleveland Clinic

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  6. Tamoxifen use may be extended to 10 years based on new data demonstrating additional benefit. Women taking tamoxifen should be informed about the risks of.

    • Tamoxifen and Uterine Cancer - ACOG.
    • Tamoxifen for Breast Cancer Treatment - Side Effects Susan G..
    • Tamoxifen and Raloxifene for Lowering Breast Cancer Risk.

    Tamoxifen, sold under the brand name Nolvadex among others, is a medication that is used to. Use of tamoxifen has been shown to slightly increase risk of deep vein thrombosis, pulmonary embolism, and stroke. Tamoxifen is also a cause of. Do not use tamoxifen if you are pregnant. It could harm the unborn baby. Use a barrier form of birth control such as a condom or diaphragm with spermicide. A fact sheet that describes types of hormone therapy, its role in preventing and treating breast cancer, and possible side effects.

     
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